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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
11.82
Human Site:
Y437
Identified Species:
26
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
Y437
P
V
N
A
A
G
R
Y
F
N
S
K
V
P
I
Chimpanzee
Pan troglodytes
XP_513663
807
91678
Y437
P
V
N
A
A
G
R
Y
F
N
S
K
V
P
I
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
Y437
P
V
N
A
A
G
R
Y
F
D
S
K
V
P
I
Dog
Lupus familis
XP_540240
893
101055
A522
N
S
K
P
A
D
V
A
G
R
Y
F
N
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
P433
G
S
C
P
S
A
L
P
I
N
T
A
D
R
Y
Rat
Rattus norvegicus
NP_001099930
804
89584
N433
C
P
S
A
L
P
I
N
T
A
S
R
C
H
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
V427
L
Q
L
P
G
S
A
V
E
K
Q
V
M
C
Q
Chicken
Gallus gallus
XP_001235234
775
85980
R407
G
E
A
L
Q
K
H
R
S
L
Q
F
S
S
R
Frog
Xenopus laevis
NP_001084841
660
74123
Q292
L
V
H
R
A
I
A
Q
L
F
Q
K
Q
L
E
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
S202
P
D
H
D
V
P
S
S
F
D
S
I
L
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S456
G
G
T
Q
T
T
P
S
S
P
T
P
T
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
100
93.3
6.6
N.A.
6.6
13.3
N.A.
0
0
20
20
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
6.6
N.A.
20
26.6
N.A.
6.6
0
26.6
46.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
37
46
10
19
10
0
10
0
10
0
0
0
% A
% Cys:
10
0
10
0
0
0
0
0
0
0
0
0
10
10
0
% C
% Asp:
0
10
0
10
0
10
0
0
0
19
0
0
10
10
0
% D
% Glu:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
37
10
0
19
0
0
0
% F
% Gly:
28
10
0
0
10
28
0
0
10
0
0
0
0
0
0
% G
% His:
0
0
19
0
0
0
10
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
10
10
0
10
0
0
10
0
0
28
% I
% Lys:
0
0
10
0
0
10
0
0
0
10
0
37
0
0
10
% K
% Leu:
19
0
10
10
10
0
10
0
10
10
0
0
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% M
% Asn:
10
0
28
0
0
0
0
10
0
28
0
0
10
0
10
% N
% Pro:
37
10
0
28
0
19
10
10
0
10
0
10
0
28
0
% P
% Gln:
0
10
0
10
10
0
0
10
0
0
28
0
10
0
10
% Q
% Arg:
0
0
0
10
0
0
28
10
0
10
0
10
0
10
10
% R
% Ser:
0
19
10
0
10
10
10
19
19
0
46
0
10
28
0
% S
% Thr:
0
0
10
0
10
10
0
0
10
0
19
0
10
0
0
% T
% Val:
0
37
0
0
10
0
10
10
0
0
0
10
28
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
28
0
0
10
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _